Protein Details: Potassium voltage-gated channel subfamily C member 4

Protein ID

ICDB_Pro_0759

Protein Name

Potassium voltage-gated channel subfamily C member 4

Gene Name

KCNC4; C1orf30

Organism

Homo sapiens (Human)

Length

635 amino acids

AlphaFoldDB

AF-Q03721-F1-model_v4.pdb

Function

This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane;the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient

Sequence

MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTCSDTSPPAREEGMIERKRADSKQNGDANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNKKAAACFLLSTGDYACADGSVRKGTFVLRDLPLQHSPEAACPPTAGTLFLPH

PDB Structures

1B4G 1B4I 1ZTN

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7 and Night Blindness;Congenital Stationary;Type 1C

Location

DOI ID

10.1098/rspb.1992.0036; 10.1038/nature04727; 10.1101/gr.2596504; 10.1016/0896-6273(94)90425-1; 10.1085/jgp.112.1.71; 10.1038/385272a0; 10.1038/5833

RefSeq

NP_001034663.1 [Q03721-3]; NP_004969.2 [Q03721-1]